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Kava dermopathy

Author: Georgina Harvey, Dermatology Registrar, Adelaide, Australia. DermNet New Zealand Editor in Chief: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Copy editor: Maria McGivern. March 2017.


Kava Dermopathy - 代码和概念
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什么是卡瓦?

卡瓦工厂是黑胡椒家族的成员(Piper methysticum)传统上用于南太平洋以制造一个psychotropic在文化仪式中消耗的饮料以及社交 - 饮料也被称为Kava [1-3]。

Kava is made by infusing the dried roots of the kava plant in water, or less commonly, in coconut milk [2].

Forest & Kim Starr via Wikimedia Commons Kava root by Mark Heard on Flickr 在Flickr上准备Kava by Dave Lonsdale

卡瓦叶Forest & Kim Starr

Kava root byMark Heard on Flickr Preparing kava byDave Lonsdale on Flickr

什么是卡瓦dermopathy?

Kava Dermopathy是一种皮肤病,发生在经常消耗Kava [1]的患者中。在斐济,Kava Dermopathy被称为Kanikani [2],而在澳大利亚,它也被称为鳄鱼皮[4]。

Kava dermopathy

Who gets kava dermopathy?

Kava dermopathy occurs in people who are regular or heavy consumers of kava [2,3].

最常发生在南太平洋和北北部土着人口[4]。

What causes kava dermopathy?

The cause of kava dermopathy is unknown; however, there are many hypotheses including [2]:

  • 干扰cholesterol代谢
  • Accumulation of kavalactones or flavopigments
  • Allergicsystemiccontact皮炎
  • Defective cytochrome P450enzymes[4].

What are the clinical features of kava dermopathy?

  • Therashfrom kava dermopathy often begins on head, face and neck, and gradually becomes moregeneralised[4].
  • The rash is ichthyosiform (resemblingIchthyosis); that is, rough, dry and鳞片状的
  • Thearepolygonal在形状。
  • The rash lackserythema[2].
  • 我t may be more evident in areas of skin exposed to the sun [3].
  • There is often associatedpalmoplantarkeratoderma[2].
  • Facial swelling and头发lossmay also occur [3].
  • Some patients complain offlushing
  • Kava Dermopathy可能有一个相关的外围神经病, resulting in numb or tingling hands and feet.

Kava Dermopathy如何被诊断出来?

Kava dermopathy is usually a clinical diagnosis, taking into account the physical features and the history, including a history of regular kava consumption, in addition to the resolution of the rash on thecessation卡瓦消费[4]。

What is thedifferential diagnosisKava Dermopathy?

Other ichthyotic disorders may appear similar to kava dermopathy. Ichthyotic disorders can be distinguished based on the patient’s history.

我nheritedIchthyosiswill usually occur at a much younger age and may becongenital(eg,清晰度病变寻常症recessive X-linked ichthyosis).

Other causes of acquired ichthyosis include [5]:

  • Malignancy
  • Abnormalityof vitamin andlipidabsorption
  • 药物(例如,降胆固醇降低药物,烟酸)
  • 我nfections, such as人类免疫缺陷病毒 (HIV),leprosy, humanT-celllymphotropic virus type 1 (HTLV-1).

What is the treatment for kava dermopathy?

当停止Kava的消耗停止时,Kava Dermopathy清除了[3,4]。

General measures to manage the rash include:

What is the outcome for kava dermopathy?

Ongoing kava consumption will result inpersistence和likely progression of kava dermopathy.

参考

  1. Clough AR, Jacups SP, Wang Z, et al. Health effects of kava use in an eastern Arnhem Land Aboriginal community. Intern Med J. 2003; 33: 336–40.PubMed
  2. Hannam S, Murray M, Romani L, Tuicakau M, Whitfeld MJ. Kava dermopathy in Fiji: an acquired ichthyosis? Int J Dermatol. 2014; 53: 1490–4. DOI: 10.1111/ijd.12546.杂志
  3. Heyes C, Tait C, Toholka R, Gebauer K. Non-infectious skin disease in Indigenous Australians. Australas J Dermatol. 2014; 55: 176–84. DOI: 10.1111/ajd.12106.PubMed
  4. 绿色,Dyall-Smith d·卡瓦胡椒的皮肤病。我n: Green A, Dyall-Smith D. A handbook of skin conditions in Aboriginal populations of Australia, 2nd edn. Carlton South, Vic.: Blackwell Science Asia, 2007.
  5. Vinzenz O, Metze D, Traupe H. Chapter 65: Inherited disorders of cornification. In: Griffiths C , Barker B, Bleiker T, Chalmers R, Creamer D (eds). Rook’s textbook of dermatology, 9th edn. Chichester: John Wiley & Sons, 2016.

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