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Erythema infectiosum

作者:亲爱的/阿曼达·奥克利教授,北京医学ogist, Hamilton, New Zealand, 1998. Updated September 2015.


What iserythemainfectiosum?

Erythema infectiosum is a common childhoodinfectioncausing a slapped cheek appearance and arash. It is also known as fifth disease and human erythrovirus infection.

What is the cause of erythema infectiosum?

Erythema infectiosum is caused by an erythrovirus, EVB19 or Parvovirus B19. It is a single-strandedDNAvirus that targets red cells in the bone marrow. It spreads via respiratory droplets, and has anincubationperiod of 7–10 days.

Who gets erythema infectiosum?

Erythema infectiosum most commonly affects young children and often occurs in several members of the family or school class. Thirty percent of infected individuals have no symptoms. It can also affect adults that have not been previously exposed to the virus.

Erythema infectiosum

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What are the symptoms of erythema infectiosum?

Parvovirus B19 infection causes nonspecific viral symptoms such as mildfeverand headache at first. The rash, erythema infectiosum, appears a few days later with firm red cheeks, which feel burning hot. This lasts 2 to 4 days, and is followed by a pink rash on the limbs and sometimes the trunk. This develops a lace-like or network pattern.

Although most prominent in the first few days, the rash canpersistfor up to six weeks at least intermittently, and is most obvious when warm.

Complications of erythema infectiosum

Although usually a mild childhood condition, erythrovirus B19 infection can result in complications. These include:

  • Polyarthropathy in infected adults (painful, swollen joints)
  • Aplastic crisis or potentially dangerous low blood cell count in patients withhaemolyticblood disorders such asautoimmunehaemolyticanaemiaand sickle cell disease
  • Spontaneous abortion,intrauterinedeath (9%) or hydrops fetalis in 3% of the offspring of infected pregnant women. This can occur if erythema infectiosum occurs in the first half of pregnancy. Parvovirus B19 does not causecongenitalmalformations. As the risk of an adverse outcome is low, the infection is not routinely screened for in pregnancy
  • Chronicparvovirus infection in immunodeficient patients, such as organtransplantrecipients, causing erythropoietin-resistant anaemia, proteinuria, and glomerulosclerosis in arenalallograft
  • Rarely,encephalitis,hepatitis, non-occlusivebowelinfarction, amegakaryocyticthrombocytopenia,myositisand heart disease

How is the diagnosis of erythema infectiosum made?

In most cases, erythema infectiosum is a clinical diagnosis in a child with characteristic slapped cheek and lacy rash. Parvovirus can cause otherrashessuch as apapularpurpuricgloves and sockssyndrome. The diagnosis can be confirmed by blood tests.

  • Parvovirusserology:IgG,IgM. This test is reported in about 7 days.
  • ParvovirusPCRis more sensitive. This test is reported in about 3 days.
  • In situhybridisation orimmunohistochemistryonbiopsyspecimens

If the child is unwell, or has haemolytic anaemia, a full blood count should be performed.Ultrasoundexamination and Doppler examination of at-risk pregancies can detect hydrops fetalis.

Treatment of erythema infectiosum

Erythema infectiosum is not generally a serious condition. There is no specific treatment. Affected children may remain at school, as the infectious stage or viraemia occurs before the rash is evident.

  • The application of an ice-cold flannel can relieve the discomfort of burning hot cheeks.
  • Red blood cell transfusions andimmunoglobulintherapycan be successful in chronic parvovirus infection or during an aplastic crisis.
  • Hydrops fetalis due to parvovirus infection is treated by intrauterine transfusion.


  • Kishore J. Real time PCR reconfirmed three novel clinical associations of parvovirus B19: Non-occlusive bowel gangrene, amegakaryocytic thrombocytopenia & myositis. Indian J Med Res [serial online] 2015 [cited 2015 Sep 16];142:88–9.Journal
  • Bihari C, Rastogi A, Saxena P, et al. Parvovirus B19 Associated Hepatitis. Hepatitis Research and Treatment. 2013;2013:472027. doi:10.1155/2013/472027.PubMed
  • Lamont RF, Sobel J, Vaisbuch E, et al. Parvovirus B19 Infection in Human Pregnancy. BJOG : an international journal of obstetrics and gynaecology. 2011;118(2):175–86. doi:10.1111/j.1471-0528.2010.02749.x.PubMed
  • Barah F, Whiteside S, Batista S, Morris J. Neurological aspects of human parvovirus B19 infection: a systematic review. Reviews in Medical Virology. 2014;24(3):154–68. doi:10.1002/rmv.1782.PubMed
  • Servey JT, Reamy BV, Hodge J. Clinical presentations of parvovirus B19 infection. Am Fam Physician. 2007 Feb 1;75(3):373–6. Review.PubMedPMID: 17304869.

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